Triads, pentads and classic presentations (part 5)

Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP)  belong to the group of diseases of thrombotic microangiopathies. In these conditions, there is thrombosis in the capillaries secondary to damage to the endothelium. This leads to  thrombocytopenia, microangiopathic haemolytic anaemia, microvascular occlusion, and organ dysfunction (e.g. kidneys, brain).

Hemolytic uremic syndrome can be described by a classic triad. The classic pentad for thrombotic thrombocytopenic purpura includes the triad of HUS plus two additional signs.

Classic triad of HUS: (1) Microangiopathic anemia, (2) thrombocytopenia, (3) acute renal failure.

Classic pentad of TTP: (1) Microangiopathic anemia, (2) thrombocytopenia, (3) acute renal failure, (4) fever, (5) fluctuating neurologic abnormalities.

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Triads, pentads and classic presentations (part 4)

As promised, here is part 4 of the “triads, pentads and classic presentations” series. The WM always welcomes any contributions for future editions!

  • Triad of Henoch-Schonlein Purpura: (1) Abdominal Pain, (2) Purpura, (3) Arthritis
  • Three specific signs of Graves disease: (1) Exophthalmos, (2) Pretibial myxedema, (3) Thyroid bruit
  • Cushing’s triad for elevated intracranial pressure: (1) Bradycardia, (2) Bradypnea, (3) Hypertension

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Have a great week!! Thank you all for reading.

Follow The Weekly Mnemonic to receive weekly posts directly in your inbox! Just enter your email address in the box on the top of the menu on the right and click “Follow”.

Click here to share a mnemonic for a future edition of The Weekly Mnemonic.